Title : Mapping SLCO1B1 Genetic Variation for Global Precision Medicine in Understudied Regions in Africa: A Focus on Zulu and Cape Admixed Populations.

Pub. Date : 2016 Sep

PMID : 27631194






1 Functional Relationships(s)
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1 Well-characterized haplotypes, *5 (RS4149056C) and *15 (RS4149056T), have been associated with a strikingly reduced uptake of multiple OATP1B1 substrates, including estrone-3-sulfate, estradiol-17beta-d-glucuronide, atorvastatin, cerivastatin, pravastatin, and rifampicin. estradiol-17 beta-glucuronide solute carrier organic anion transporter family member 1B1 Homo sapiens