Pub. Date : 2016 Sep 14
PMID : 27624942
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The identification of cancer-associated mutations in the tricarboxylic acid (TCA) cycle enzymes isocitrate dehydrogenases 1 and 2 (IDH1/2) highlights the prevailing notion that aberrant metabolic function can contribute to carcinogenesis. | Tricarboxylic Acids | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 2 | The identification of cancer-associated mutations in the tricarboxylic acid (TCA) cycle enzymes isocitrate dehydrogenases 1 and 2 (IDH1/2) highlights the prevailing notion that aberrant metabolic function can contribute to carcinogenesis. | Tricarboxylic Acids | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 3 | Our results provide an additional molecular mechanism for the oncogenic activity of mutant IDH1/2 by revealing an unprecedented link between TCA cycle defects and positive modulation of mTOR function downstream of the canonical PI3K/AKT/TSC1-2 pathway. | Tricarboxylic Acids | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |