PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27624942-1 2016 The identification of cancer-associated mutations in the tricarboxylic acid (TCA) cycle enzymes isocitrate dehydrogenases 1 and 2 (IDH1/2) highlights the prevailing notion that aberrant metabolic function can contribute to carcinogenesis. Tricarboxylic Acids 57-75 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 131-137 27624942-1 2016 The identification of cancer-associated mutations in the tricarboxylic acid (TCA) cycle enzymes isocitrate dehydrogenases 1 and 2 (IDH1/2) highlights the prevailing notion that aberrant metabolic function can contribute to carcinogenesis. Tricarboxylic Acids 77-80 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 131-137 27624942-7 2016 Our results provide an additional molecular mechanism for the oncogenic activity of mutant IDH1/2 by revealing an unprecedented link between TCA cycle defects and positive modulation of mTOR function downstream of the canonical PI3K/AKT/TSC1-2 pathway. Tricarboxylic Acids 141-144 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 91-97