Pub. Date : 2016 Aug 18
PMID : 27621764
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS: Expression of P-glycoprotein (P-gp) and NF-kappaB in human HepG2 or HepG2/adriamycin (ADM) cells treated with pCMV-NF-kappaB-small interference RNA (siRNA) with or without metformin, was analyzed by Western blot or fluorescence quantitative PCR. | Metformin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | METHODS: Expression of P-glycoprotein (P-gp) and NF-kappaB in human HepG2 or HepG2/adriamycin (ADM) cells treated with pCMV-NF-kappaB-small interference RNA (siRNA) with or without metformin, was analyzed by Western blot or fluorescence quantitative PCR. | Metformin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | After pretreatment with metformin, HepG2/ADM cells were sensitized to doxorubicin and P-gp was decreased through the NF-kappaB signaling pathway. | Metformin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | CONCLUSION: Metformin via silencing NF-kappaB signaling could effectively reverse MDR of HCC cells by down-regulating MDR1/P-gp expression. | Metformin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | CONCLUSION: Metformin via silencing NF-kappaB signaling could effectively reverse MDR of HCC cells by down-regulating MDR1/P-gp expression. | Metformin | ATP binding cassette subfamily B member 1 | Homo sapiens |