Title : Heme oxygenase-1-mediated apoptosis under cadmium-induced oxidative stress is regulated by autophagy, which is sensitized by tumor suppressor p53.

Pub. Date : 2016 Oct 7

PMID : 27620489






2 Functional Relationships(s)
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1 In both cell lines, Cd exposure resulted in caspase-3-mediated PARP-1 cleavage and the induction of CHOP, LC3-II, and HO-1, which were limited in YD10B and H1299 cells exposed to high concentrations of Cd. Cadmium DNA damage inducible transcript 3 Homo sapiens
2 The inhibition of autophagy using small interfering RNA (siRNA) for the autophagy-related gene atg5 enhanced HO-1, CHOP, and PARP-1 cleavage induced by Cd. Cadmium DNA damage inducible transcript 3 Homo sapiens