Title : An intracellular adrenomedullin system reduces IL-6 release via a NF-kB-mediated, cAMP-independent transcriptional mechanism in rat thymic epithelial cells.

Pub. Date : 2016 Dec

PMID : 27619517






2 Functional Relationships(s)
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1 Pretreatment of TECs for 4h with ADM significantly reduced lipopolysaccharide (LPS)-induced release of IL-6 (P<0.001) and expression of the p65 subunit of NF-kB, while doubled the expression of IkBalpha (P<0.001), the physiological inhibitor of NF-kB nuclear translocation. 4h RELA proto-oncogene, NF-kB subunit Rattus norvegicus
2 Pretreatment of TECs for 4h with ADM significantly reduced lipopolysaccharide (LPS)-induced release of IL-6 (P<0.001) and expression of the p65 subunit of NF-kB, while doubled the expression of IkBalpha (P<0.001), the physiological inhibitor of NF-kB nuclear translocation. 4h RELA proto-oncogene, NF-kB subunit Rattus norvegicus