Title : Selective and differential interactions of BNN27, a novel C17-spiroepoxy steroid derivative, with TrkA receptors, regulating neuronal survival and differentiation.

Pub. Date : 2016 Dec

PMID : 27618740






2 Functional Relationships(s)
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1 Here, we provide evidence that a novel C17-spiroepoxy steroid derivative, BNN27, specifically interacts with and activates the TrkA receptor of NGF, inducing phosphorylation of TrkA tyrosine residues and down-stream neuronal survival-related kinase signaling. Tyrosine neurotrophic tyrosine kinase, receptor, type 1 Mus musculus
2 Here, we provide evidence that a novel C17-spiroepoxy steroid derivative, BNN27, specifically interacts with and activates the TrkA receptor of NGF, inducing phosphorylation of TrkA tyrosine residues and down-stream neuronal survival-related kinase signaling. Tyrosine neurotrophic tyrosine kinase, receptor, type 1 Mus musculus