Pub. Date : 2016 Nov 1
PMID : 27612966
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Acrolein and thiol-reactive electrophiles suppress allergen-induced innate airway epithelial responses by inhibition of DUOX1 and EGFR. | Sulfhydryl Compounds | dual oxidase 1 | Mus musculus |
| 2 | Acrolein and other thiol-reactive electrophiles were found to dramatically prevent allergen-induced activation of DUOX1 as well as EGFR, and acrolein was capable of inhibiting EGFR tyrosine kinase activity via modification of C797. | Sulfhydryl Compounds | dual oxidase 1 | Mus musculus |
| 3 | Collectively, our findings indicate a novel anti-inflammatory mechanism of CS-derived acrolein and other thiol-reactive electrophiles, by directly inhibiting DUOX1- and EGFR-mediated airway epithelial responses to airborne allergens. | Sulfhydryl Compounds | dual oxidase 1 | Mus musculus |