PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27612966-0 2016 Acrolein and thiol-reactive electrophiles suppress allergen-induced innate airway epithelial responses by inhibition of DUOX1 and EGFR. Sulfhydryl Compounds 13-18 dual oxidase 1 Mus musculus 120-125 27612966-5 2016 Acrolein and other thiol-reactive electrophiles were found to dramatically prevent allergen-induced activation of DUOX1 as well as EGFR, and acrolein was capable of inhibiting EGFR tyrosine kinase activity via modification of C797. Sulfhydryl Compounds 19-24 dual oxidase 1 Mus musculus 114-119 27612966-7 2016 Collectively, our findings indicate a novel anti-inflammatory mechanism of CS-derived acrolein and other thiol-reactive electrophiles, by directly inhibiting DUOX1- and EGFR-mediated airway epithelial responses to airborne allergens. Sulfhydryl Compounds 105-110 dual oxidase 1 Mus musculus 158-163