Pub. Date : 2017 Jan
PMID : 27603596
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tunicamycin enhances human colon cancer cells to TRAIL-induced apoptosis by JNK-CHOP-mediated DR5 upregulation and the inhibition of the EGFR pathway. | Tunicamycin | epidermal growth factor receptor | Homo sapiens |
| 2 | In addition, tunicamycin inhibited epidermal growth factor receptor glycosylation and the downstream signaling pathways, Akt and extracellular signal-regulated kinases activation, which might also be required for TRAIL sensitization by tunicamycin. | Tunicamycin | epidermal growth factor receptor | Homo sapiens |
| 3 | In addition, tunicamycin inhibited epidermal growth factor receptor glycosylation and the downstream signaling pathways, Akt and extracellular signal-regulated kinases activation, which might also be required for TRAIL sensitization by tunicamycin. | Tunicamycin | epidermal growth factor receptor | Homo sapiens |
| 4 | In summary, tunicamycin effectively enhanced TRAIL-induced apoptosis might through JNK-CHOP-mediated DR5 upregulation and the inhibition of the epidermal growth factor receptor pathway. | Tunicamycin | epidermal growth factor receptor | Homo sapiens |