Title : 25-Hydroxycholesterol impairs endothelial function and vasodilation by uncoupling and inhibiting endothelial nitric oxide synthase.

Pub. Date : 2016 Oct 1

PMID : 27600825






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 25-OHC reduced the phosphorylation of Akt and eNOS and the association of eNOS and HSP90. 25-hydroxycholesterol nitric oxide synthase 3 Rattus norvegicus
2 25-OHC reduced the phosphorylation of Akt and eNOS and the association of eNOS and HSP90. 25-hydroxycholesterol nitric oxide synthase 3 Rattus norvegicus
3 These data demonstrated that 25-OHC could impair endothelial function by uncoupling and inhibiting eNOS activity as well as by inducing endothelial cell apoptosis. 25-hydroxycholesterol nitric oxide synthase 3 Rattus norvegicus