Title : Celastrol modulates inflammation through inhibition of the catalytic activity of mediators of arachidonic acid pathway: Secretory phospholipase A2 group IIA, 5-lipoxygenase and cyclooxygenase-2.

Pub. Date : 2016 Nov

PMID : 27597642






3 Functional Relationships(s)
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1 Celastrol modulates inflammation through inhibition of the catalytic activity of mediators of arachidonic acid pathway: Secretory phospholipase A2 group IIA, 5-lipoxygenase and cyclooxygenase-2. celastrol prostaglandin-endoperoxide synthase 2 Homo sapiens
2 We provide the first evidence for celastrol"s ability to inhibit the catalytic activity of sPLA2IIA, 5-LOX and COX-2 enzymes. celastrol prostaglandin-endoperoxide synthase 2 Homo sapiens
3 In addition, celastrol inhibited the catalytic activities of 5-LOX (IC50=5muM) and COX-2 (IC50=20muM) in vitro; sPLA2IIA-induced edema and carrageenan-induced edema in mice; and lipopolysaccharide-stimulated production of PGE2 in human neutrophils. celastrol prostaglandin-endoperoxide synthase 2 Homo sapiens