Title : Prunella vulgaris Polysaccharide Inhibits Growth and Migration of Breast Carcinoma-Associated Fibroblasts by Suppressing Expression of Basic Fibroblast Growth Factor.

Pub. Date : 2020 Apr

PMID : 27586473






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 bFGF promoted CAFs proliferation (P <0.01) and migration (P <0.01), protected CAFs from apoptosis (P <0.05) and reduced G0 phase to 49.06% (P <0.01). cafs fibroblast growth factor 2 Homo sapiens
2 bFGF promoted CAFs proliferation (P <0.01) and migration (P <0.01), protected CAFs from apoptosis (P <0.05) and reduced G0 phase to 49.06% (P <0.01). cafs fibroblast growth factor 2 Homo sapiens
3 However, these effects of bFGF on CAFs could be abrogated by PVP. cafs fibroblast growth factor 2 Homo sapiens
4 Moreover, PVP reduced the mRNA expression (P <0.01) and protein secretion of bFGF (P <0.01) in CAFs. cafs fibroblast growth factor 2 Homo sapiens
5 CONCLUSION: PVP could exert an anti-cancer effect on breast CAFs by inhibiting bFGF expression, thus inhibiting the growth of breast cancer SKBr-3 cells indirectly. cafs fibroblast growth factor 2 Homo sapiens