Pub. Date : 2016 Nov 15
PMID : 27581986
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Structure of an N276-Dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole Adjacent to the CD4 Binding Site. | Polysaccharides | CD4 molecule | Homo sapiens |
| 2 | These glycan-free V5 loops are unusual holes in the glycan shield that may have been necessary for initiating this N276 glycan-dependent CD4 binding site B-cell lineage. | Polysaccharides | CD4 molecule | Homo sapiens |
| 3 | These glycan-free V5 loops are unusual holes in the glycan shield that may have been necessary for initiating this N276 glycan-dependent CD4 binding site B-cell lineage. | Polysaccharides | CD4 molecule | Homo sapiens |
| 4 | These glycan-free V5 loops are unusual holes in the glycan shield that may have been necessary for initiating this N276 glycan-dependent CD4 binding site B-cell lineage. | Polysaccharides | CD4 molecule | Homo sapiens |
| 5 | In this study, we isolate a narrowly neutralizing N276 glycan-dependent antibody and use X-ray crystallography and viral deep sequencing to describe how gp120 lacking glycans in V5 might have elicited these early glycan-dependent CD4 binding site antibodies. | Polysaccharides | CD4 molecule | Homo sapiens |
| 6 | These data highlight how glycan holes can play a role in the elicitation of B-cell lineages targeting the CD4 binding site. | Polysaccharides | CD4 molecule | Homo sapiens |