Title : In silico design of novel hERG-neutral sildenafil-like PDE5 inhibitors.

Pub. Date : 2017 Oct

PMID : 27581752






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Patch clamp experiments showed that the IC50 values of the human ether-a-go-go-related gene (hERG1) potassium (K) ion channel blocking affinity of PDE5 inhibitors sildenafil, vardenafil, and tadalafil as 33, 12, and 100 muM, respectively. Tadalafil phosphodiesterase 5A Homo sapiens