Pub. Date : 2016 Oct 1
PMID : 27580989
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Curcumin Suppresses Proliferation and Migration and Induces Apoptosis on Human Placental Choriocarcinoma Cells via ERK1/2 and SAPK/JNK MAPK Signaling Pathways. | Curcumin | mitogen-activated protein kinase 3 | Homo sapiens |
2 | Curcumin Suppresses Proliferation and Migration and Induces Apoptosis on Human Placental Choriocarcinoma Cells via ERK1/2 and SAPK/JNK MAPK Signaling Pathways. | Curcumin | mitogen-activated protein kinase 3 | Homo sapiens |
3 | The ERK1/2 and SAPK/JNK and their downstream molecules including P90RSK and c-Jun, respectively, were activated by curcumin. | Curcumin | mitogen-activated protein kinase 3 | Homo sapiens |
4 | Moreover, pharmacological inhibitors of ERK1/2 (U0126) and SAPK/JNK (SP600125) suppressed ERK1/2 and SAPK/JNK activation respectively, and blockage of P38 MAPK by its inhibitor (SB203580) had a synergistic effect with curcumin. | Curcumin | mitogen-activated protein kinase 3 | Homo sapiens |
5 | These results indicate that curcumin acts as a novel chemotherapeutic agent on human placental choriocarcinoma cells via activation of ERK1/2 and SAPK/JNK signal transduction cascades. | Curcumin | mitogen-activated protein kinase 3 | Homo sapiens |