Title : DNA synthesis in Alzheimer type II astrocytosis. The question of astrocytic proliferation and mitosis in experimentally induced hepatic encephalopathy.

Pub. Date : 1989 Aug

PMID : 2757524






1 Functional Relationships(s)
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1 A model of hepatic encephalopathy can be produced using methionine sulfoximine to inhibit irreversibly the enzyme glutamine synthetase, resulting in elevated brain ammonia levels and development of Alzheimer type II astrocytosis. Ammonia glutamate-ammonia ligase Rattus norvegicus