Title : Inhibition of nuclear factor kappaB proteins-platinated DNA interactions correlates with cytotoxic effectiveness of the platinum complexes.

Pub. Date : 2016 Aug 30

PMID : 27574114






2 Functional Relationships(s)
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1 Using gel-mobility-shift assays and surface plasmon resonance spectroscopy we examined the interactions of NF-kappaB proteins with oligodeoxyribonucleotide duplexes containing kappaB site damaged by DNA adducts of three platinum complexes. Platinum nuclear factor kappa B subunit 1 Homo sapiens
2 The results indicate that structurally different DNA adducts of these platinum complexes exhibit a different efficiency to affect the affinity of the platinated DNA (kappaB sites) to NF-kappaB proteins. Platinum nuclear factor kappa B subunit 1 Homo sapiens