Title : MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL.

Pub. Date : 2016 Aug 25

PMID : 27560714






2 Functional Relationships(s)
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1 By combining inducible knockout mouse models with the BH3-mimetic compound ABT-737, which inhibits BCL-2, BCL-XL and BCL-W, we found that dependency on MCL-1, BCL-XL or BCL-2 expression changes during B-cell development. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid BCL2-like 1 Mus musculus
2 By combining inducible knockout mouse models with the BH3-mimetic compound ABT-737, which inhibits BCL-2, BCL-XL and BCL-W, we found that dependency on MCL-1, BCL-XL or BCL-2 expression changes during B-cell development. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid BCL2-like 1 Mus musculus