Protein Name BCL2-like 1
Organism Mus musculus
Gene ID 12048
Gene Symbol

Bcl2l1

UniProt Q64373 (B2CL1_MOUSE), Q5HZH3 (Q5HZH3_MOUSE), O35843 (O35843_MOUSE)
Relationships Total Number of functionally related compound(s) : 377
Total Number of Articles : 502
Description

BCL2-like 1

Gene Summary

This gene encodes a member of the Bcl-2 family of apoptosis regulators. The encoded protein is localized to the inner and outer mitochondrial membranes and regulates the programmed cell death pathway during development and tissue homeostasis. This protein binds to voltage-dependent anion channels in the outer mitochondrial membrane to facilitate the uptake of calcium ions. Mice embryos lacking this gene survived for two weeks and exhibited cell death of immature hematopoietic cells and neurons. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jan 2014]

synonyms
  • bcl-2-like protein 1
  • B-cell leukemia/lymphoma x
  • anti-apoptosis regulatory protein
Click to show/hide the synonyms
Properties