Title : Nanosecond Dynamics of Gαi1 Bound to Nucleotides or Ric-8A, a Gα Chaperone with GEF Activity.

Pub. Date : 2016 Aug 23

PMID : 27558716






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Resistance to Inhibitors of Cholinesterase A (Ric-8A) is a 60-kDa cytosolic protein that has chaperone and guanine nucleotide exchange (GEF) activity toward heterotrimeric G protein alpha subunits of the i, q, and 12/13 classes, catalyzing the release of GDP from Galpha and subsequent binding of GTP. Guanosine Diphosphate succinate-CoA ligase GDP/ADP-forming subunit alpha Homo sapiens
2 In the absence of GTP or GTP analogs, and subsequent to GDP release, Galpha forms a stable nucleotide-free complex with Ric-8A. Guanosine Diphosphate succinate-CoA ligase GDP/ADP-forming subunit alpha Homo sapiens