Pub. Date : 2015
PMID : 27551463
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SAG-UPS attenuates proapoptotic SARM and Noxa to confer survival advantage to early hepatocellular carcinoma. | sagopilone | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 2 | SAG-overexpressing HCC cell lines display reduced SARM and Noxa (but not Bcl-2, Bax and Bcl-xL), suggesting that SARM and Noxa are specific substrates of SAG-dependent ubiquitination. | sagopilone | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 3 | SAG-overexpressing HCC cell lines display reduced SARM and Noxa (but not Bcl-2, Bax and Bcl-xL), suggesting that SARM and Noxa are specific substrates of SAG-dependent ubiquitination. | sagopilone | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 4 | SAG-overexpressing HCC cell lines display reduced SARM and Noxa (but not Bcl-2, Bax and Bcl-xL), suggesting that SARM and Noxa are specific substrates of SAG-dependent ubiquitination. | sagopilone | sterile alpha and TIR motif containing 1 | Homo sapiens |
| 5 | Altogether, early stage-upregulated SAG-UPS exacerbates hepatocarcinogenesis progression, through: (1) ubiquitination-mediated degradation of proapoptotic SARM and Noxa; and (2) production of protumorigenic cytokines that induce a protumorigenic microenvironment, conferring survival advantage to HCC cells. | sagopilone | sterile alpha and TIR motif containing 1 | Homo sapiens |