Pub. Date : 2016 Sep 13
PMID : 27546461
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis. | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |
| 2 | Gene expression and functional studies demonstrated that the cellular iron importer, divalent metal transporter 1 (DMT1), is highly expressed in CRC through hypoxia-inducible factor 2alpha-dependent transcription. | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |
| 3 | Gene expression and functional studies demonstrated that the cellular iron importer, divalent metal transporter 1 (DMT1), is highly expressed in CRC through hypoxia-inducible factor 2alpha-dependent transcription. | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |
| 4 | A pharmacological inhibitor of DMT1 antagonized the ability of iron to promote tumor growth in a CRC mouse model and a patient-derived CRC enteroid orthotopic model. | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |