Pub. Date : 2016 Dec
PMID : 27544482
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Isoflurane-induced inactivation of CREB through histone deacetylase 4 is responsible for cognitive impairment in developing brain. | Isoflurane | cAMP responsive element binding protein 1 | Mus musculus |
| 2 | Here we have shown that administration of isoflurane (1.4%) for 2h leads to transcriptional inactivation of CREB which results in loss of dendritic outgrowth and decreased expression level of proteins essential for memory and cognitive functions, such as BDNF, and c-fos in the developing brain of mice at postnatal day 7 (PND7). | Isoflurane | cAMP responsive element binding protein 1 | Mus musculus |
| 3 | To elucidate the molecular mechanism, we found that exposure to isoflurane leads to an increase in nuclear translocation of HDAC4, which interacts with CREB in the nucleus. | Isoflurane | cAMP responsive element binding protein 1 | Mus musculus |
| 4 | Taken together, our study suggests that HDAC4-induced transcriptional inactivation of CREB is responsible for isoflurane-induced cognitive dysfunction in the brain. | Isoflurane | cAMP responsive element binding protein 1 | Mus musculus |