Pub. Date : 2016 Oct
PMID : 27535835
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Silencing of fused toes homolog enhances cisplatin sensitivity in cervical cancer cells by inhibiting epidermal growth factor receptor-mediated repair of DNA damage. | Cisplatin | epidermal growth factor receptor | Homo sapiens |
| 2 | EGFR is activated by cisplatin, and this may lead to resistance to this drug. | Cisplatin | epidermal growth factor receptor | Homo sapiens |
| 3 | RESULTS: Among the lines tested, ME180 cells showed the highest basal expression of EGFR and increased nuclear phosphorylated EGFR in response to cisplatin. | Cisplatin | epidermal growth factor receptor | Homo sapiens |
| 4 | RESULTS: Among the lines tested, ME180 cells showed the highest basal expression of EGFR and increased nuclear phosphorylated EGFR in response to cisplatin. | Cisplatin | epidermal growth factor receptor | Homo sapiens |
| 5 | In ME180 cells, the activation of EGFR and DNA-PK by cisplatin was attenuated by silencing FTS. | Cisplatin | epidermal growth factor receptor | Homo sapiens |
| 6 | CONCLUSION: FTS is involved in EGFR-mediated repair of DNA damage induced by cisplatin in ME180 cells. | Cisplatin | epidermal growth factor receptor | Homo sapiens |
| 7 | This suggests that FTS can be a target to increase the efficacy of cisplatin in cervical cancer cells that exhibit increased nuclear phosphorylated EGFR in response to cisplatin. | Cisplatin | epidermal growth factor receptor | Homo sapiens |
| 8 | This suggests that FTS can be a target to increase the efficacy of cisplatin in cervical cancer cells that exhibit increased nuclear phosphorylated EGFR in response to cisplatin. | Cisplatin | epidermal growth factor receptor | Homo sapiens |