Title : Pulmonary inflammation and fibrosis in a murine model of asbestosis and silicosis. Possible role of tumor necrosis factor.

Pub. Date : 1989 Jun

PMID : 2753523






4 Functional Relationships(s)
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1 TNF production in silica-instilled mice was similar to controls, possibly due to the presence of large numbers of neutrophils (3.3 x 10(5)/lavage) that could adsorb TNF. Silicon Dioxide tumor necrosis factor Mus musculus
2 TNF production in silica-instilled mice was similar to controls, possibly due to the presence of large numbers of neutrophils (3.3 x 10(5)/lavage) that could adsorb TNF. Silicon Dioxide tumor necrosis factor Mus musculus
3 In vitro experiments showed an augmentation of TNF production by bronchoalveolar cells in the presence of silica. Silicon Dioxide tumor necrosis factor Mus musculus
4 Taken together, our data suggest that asbestos and silica stimulate alveolar macrophages to produce TNF, which can be involved in pulmonary inflammation and fibrosis. Silicon Dioxide tumor necrosis factor Mus musculus