Title : Backbone Modification of a Parathyroid Hormone Receptor-1 Antagonist/Inverse Agonist.

Pub. Date : 2016 Oct 21

PMID : 27533344






1 Functional Relationships(s)
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1 We show that backbone modification via periodic replacement of alpha-amino acid residues with homologous beta-amino acid residues leads to an alpha/beta-PTH(7-34) peptide that retains the antagonist and inverse agonist activities of the prototype alpha-peptide while exhibiting enhanced stability in the presence of aggressive proteases. Amino Acids parathyroid hormone Homo sapiens