Title : Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming.

Pub. Date : 2016 Nov

PMID : 27530298






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The cytosolic and mitochondrial isoforms of serine hydroxymethyltransferase (SHMT1 and SHMT2, respectively) are well-recognized targets of cancer research, since their activity is critical for purine and pyrimidine biosynthesis and because of their prominent role in the metabolic reprogramming of cancer cells. pyrimidine serine hydroxymethyltransferase 1 Homo sapiens