Protein Name serine hydroxymethyltransferase 1
Organism Homo sapiens
Gene ID 6470
Gene Symbol


UniProt P34896 (GLYC_HUMAN)
Relationships Total Number of functionally related compound(s) : 126
Total Number of Articles : 150

serine hydroxymethyltransferase 1

Gene Summary

This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

  • serine hydroxymethyltransferase, cytosolic
  • cytoplasmic serine hydroxymethyltransferase
  • glycine hydroxymethyltransferase
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