| Protein Name | serine hydroxymethyltransferase 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 6470 |
| Gene Symbol | SHMT1 |
| UniProt | P34896 (GLYC_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
126
Total Number of Articles : 150 |
Description |
serine hydroxymethyltransferase 1 |
| Gene Summary |
This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
| synonyms |
|
| Properties | |