Title : Inhibition of uracil DNA glycosylase sensitizes cancer cells to 5-fluorodeoxyuridine through replication fork collapse-induced DNA damage.

Pub. Date : 2016 Sep 13

PMID : 27517750






1 Functional Relationships(s)
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1 5-fluorodeoxyuridine (5-FdU, floxuridine) is active against multiple cancers through the inhibition of thymidylate synthase, which consequently introduces uracil and 5-FU incorporation into the genome. Uracil thymidylate synthetase Homo sapiens