Title : Trabectedin Is Active against Malignant Pleural Mesothelioma Cell and Xenograft Models and Synergizes with Chemotherapy and Bcl-2 Inhibition In Vitro.

Pub. Date : 2016 Oct

PMID : 27512118






1 Functional Relationships(s)
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1 Accordingly, bcl-2 inhibitors (Obatoclax, ABT-199) markedly synergized with trabectedin paralleled by deregulated expression of the bcl-2 family members bcl-2, bim, bax, Mcl-1, and bcl-xL as a consequence of trabectedin exposure. Trabectedin MCL1 apoptosis regulator, BCL2 family member Homo sapiens