Pub. Date : 2016 Jun
PMID : 27510965
4 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | In a previous study, we demonstrated that quercetin appears to be a potent anti-tumorigenic agent through its inhibition of the EGFR/Akt pathway in oral cancer, but its anti-metastatic potential in HNSCC remains unclear [1]. | Quercetin | epidermal growth factor receptor | Homo sapiens | ||
| 2 | Here, we have hypothesized that quercetin might be effective in metastatic inhibition in EGFR-overexpressing HNSCC cells. | Quercetin | epidermal growth factor receptor | Homo sapiens | ||
| 3 | Quercetin treatment with 10 muM (half concentration of IC50) suppressed cell migration and invasion in EGFR-overexpressing HSC-3 and FaDu HNSCC cells. | Quercetin | epidermal growth factor receptor | Homo sapiens | ||
| 4 | Taken together, our data indicate that quercetin is an effective anti-cancer agent against MMP-2- and MMP-9-mediated metastasis in EGFR-overexpressing HNSCC. | Quercetin | epidermal growth factor receptor | Homo sapiens | ||