Title : Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates.

Pub. Date : 2016 Aug

PMID : 27509335






2 Functional Relationships(s)
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1 Moreover, metformin induces mitochondrial dysfunction and cell death by affecting the level and conformation of Translocase of the Outer Membrane 40 (TOM40), voltage-dependent anion-selective channels 1 (VDAC1) and hexokinase I (HKI), proteins involved in mitochondrial transport of molecules, including Abeta. Metformin amyloid beta (A4) precursor protein Mus musculus
2 By using biophysical techniques we found that metformin is able to directly interact with Abeta influencing its aggregation kinetics and features. Metformin amyloid beta (A4) precursor protein Mus musculus