Title : Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling.

Pub. Date : 2016 Aug 9

PMID : 27507649






2 Functional Relationships(s)
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1 Blockade of interleukin-6 (IL-6)-JAK-STAT signaling, NF-kappaB signaling, and bromodomain extraterminal proteins, which recognize acetylated lysines and promote transcriptional elongation, significantly reduced Il-6 and Mmp13 expression in HDAC3-deficient chondrocytes and secondary activation in osteoclasts. Lysine interleukin 6 Mus musculus
2 Blockade of interleukin-6 (IL-6)-JAK-STAT signaling, NF-kappaB signaling, and bromodomain extraterminal proteins, which recognize acetylated lysines and promote transcriptional elongation, significantly reduced Il-6 and Mmp13 expression in HDAC3-deficient chondrocytes and secondary activation in osteoclasts. Lysine interleukin 6 Mus musculus