Title : Cilostazol Modulates Autophagic Degradation of β-Amyloid Peptide via SIRT1-Coupled LKB1/AMPKα Signaling in Neuronal Cells.

Pub. Date : 2016

PMID : 27494711






1 Functional Relationships(s)
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1 Cilostazol increased cathepsin B activity and decreased p62/SQSTM 1, consequently decreased accumulation of Abeta1-42 in the activated N2aSwe cells, and these results were blocked by sirtinol, compound C and bafilomycin A1 (autophagosome blocker), suggesting enhanced autophagosome formation by cilostazol. bafilomycin sequestosome 1 Mus musculus