| Protein Name | sequestosome 1 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 18412 |
| Gene Symbol | Sqstm1 |
| UniProt | Q64337 (SQSTM_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
151
Total Number of Articles : 151 |
Description |
sequestosome 1 |
| Gene Summary |
Enables several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; ionotropic glutamate receptor binding activity; and molecular condensate scaffold activity. Involved in several processes, including aggrephagy; positive regulation of long-term synaptic potentiation; and protein import into nucleus. Acts upstream of or within several processes, including brown fat cell proliferation; energy homeostasis; and negative regulation of transcription by RNA polymerase II. Located in several cellular components, including aggresome; sperm midpiece; and vacuole. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Paget's disease of bone. Human ortholog(s) of this gene implicated in Paget's disease of bone; Paget's disease of bone 3; distal myopathy with rimmed vacuoles; frontotemporal dementia and/or amyotrophic lateral sclerosis 3; and neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset. Orthologous to human SQSTM1 (sequestosome 1). [provided by Alliance of Genome Resources, Jul 2025] |
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