Title : Prenylated Chalcone 2 Acts as an Antimitotic Agent and Enhances the Chemosensitivity of Tumor Cells to Paclitaxel.

Pub. Date : 2016 Jul 29

PMID : 27483224






1 Functional Relationships(s)
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1 We previously reported that prenylated chalcone 2 (PC2), the O-prenyl derivative (2) of 2"-hydroxy-3,4,4",5,6"-pentamethoxychalcone (1), induced cytotoxicity of tumor cells via disruption of p53-MDM2 interaction. 2"-hydroxy-3,4,4",5,6"-pentamethoxychalcone MDM2 proto-oncogene Homo sapiens