Pub. Date : 2016 Sep 16
PMID : 27481942
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We report here that a population of human beta2-adrenergic receptors (beta2AR), a canonical G protein-coupled receptor, traffics along a previously undescribed intracellular itinerary via the Golgi complex that is associated with the sequential S-palmitoylation and depalmitoylation of a previously undescribed site of modification, Cys-265 within the third intracellular loop. | Cysteine | adrenoceptor beta 2 | Homo sapiens |
| 2 | We report here that a population of human beta2-adrenergic receptors (beta2AR), a canonical G protein-coupled receptor, traffics along a previously undescribed intracellular itinerary via the Golgi complex that is associated with the sequential S-palmitoylation and depalmitoylation of a previously undescribed site of modification, Cys-265 within the third intracellular loop. | Cysteine | adrenoceptor beta 2 | Homo sapiens |
| 3 | In addition, beta2AR S-palmitoylated at Cys-265 are selectively preserved under a sustained adrenergic stimulation, which results in the down-regulation and degradation of betaAR. | Cysteine | adrenoceptor beta 2 | Homo sapiens |
| 4 | Cys-265 is not conserved in beta1AR, and S-palmitoylation of Cys-265 may thus be associated with functional differences between beta2AR and beta1AR, including relative resistance of beta2AR to down-regulation in multiple pathophysiologies. | Cysteine | adrenoceptor beta 2 | Homo sapiens |
| 5 | Cys-265 is not conserved in beta1AR, and S-palmitoylation of Cys-265 may thus be associated with functional differences between beta2AR and beta1AR, including relative resistance of beta2AR to down-regulation in multiple pathophysiologies. | Cysteine | adrenoceptor beta 2 | Homo sapiens |