Pub. Date : 2016 Jul 25
PMID : 27463705
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Estrogen Receptor Signaling and the PI3K/Akt Pathway Are Involved in Betulinic Acid-Induced eNOS Activation. | betulinic acid | nitric oxide synthase 3 | Homo sapiens |
| 2 | Short-term incubation of EA.hy 926 cells with BA resulted in eNOS phosphorylation at the serine 1177 residue in a concentration- and time-dependent manner with a half-maximal effective concentration of 0.57 microM. | betulinic acid | nitric oxide synthase 3 | Homo sapiens |
| 3 | BA-induced eNOS phosphorylation and NO production was completely blocked by pretreatment with ICI 182,780, and was attenuated by pretreatment with the PI3K inhibitors wortmannin and LY294002. | betulinic acid | nitric oxide synthase 3 | Homo sapiens |
| 4 | These results indicate that fast non-genomic effects of ER with downstream signaling through the PI3K/Akt pathway and consecutive eNOS phosphorylation at serine 1177 are involved in BA-induced eNOS activation. | betulinic acid | nitric oxide synthase 3 | Homo sapiens |
| 5 | These results indicate that fast non-genomic effects of ER with downstream signaling through the PI3K/Akt pathway and consecutive eNOS phosphorylation at serine 1177 are involved in BA-induced eNOS activation. | betulinic acid | nitric oxide synthase 3 | Homo sapiens |