Title : Pentoxifylline abrogates cardiotoxicity induced by the administration of a single high dose or multiple low doses of doxorubicin in rats.

Pub. Date : 2016 Nov

PMID : 27461572






1 Functional Relationships(s)
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1 The administration of DOX in both dose regimens caused increases in serum CK-MB and LDH activities, in cardiac TNF-alpha, NO and MDA levels, as well as in the cardiac expression of iNOS, NF-kappaB, FasL and caspase-3, whereas it significantly reduced the cardiac GSH level, as well as SOD and CAT activities (P < 0.05). Doxorubicin nitric oxide synthase 2 Rattus norvegicus