Pub. Date : 2017 Jan
PMID : 27461063
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia. | idelalisib | transcription factor 3 | Homo sapiens |
| 2 | By drug-sensitivity testing of leukemic blasts from the index patient, control samples and TCF3-PBX1 positive and negative BCP-ALL cell lines, we identified the phosphatidylinositide 3-kinase delta (p110delta) inhibitor idelalisib as an effective treatment for TCF3-PBX1 BCP-ALL. | idelalisib | transcription factor 3 | Homo sapiens |
| 3 | Our results suggest that idelalisib is a promising treatment option for patients with TCF3-PBX1 BCP-ALL, whereas other drugs could be useful depending on the genetic context of individual patients. | idelalisib | transcription factor 3 | Homo sapiens |