Protein Name transcription factor 3
Organism Homo sapiens
Gene ID 6929
Gene Symbol

TCF3

UniProt P15923 (TFE2_HUMAN), X6REB3 (X6REB3_HUMAN), A0A0A0MRB7 (A0A0A0MRB7_HUMAN)
Relationships Total Number of functionally related compound(s) : 110
Total Number of Articles : 106
Description

transcription factor 3

Gene Summary

This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]

synonyms
  • transcription factor E2-alpha
  • E2A-HLF fusion transcript protein
  • NOL1-TCF3 fusion
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Properties