Pub. Date : 2016 Oct
PMID : 27454768
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Quercetin inhibits LPS-induced adhesion molecule expression and oxidant production in human aortic endothelial cells by p38-mediated Nrf2 activation and antioxidant enzyme induction. | Quercetin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
2 | Furthermore, quercetin induced activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) and subsequent mRNA and protein expression of the antioxidant enzymes, heme oxygenase-1 (HO-1), NAD(P)H dehydrogenase, quinone 1, and glutamate-cysteine ligase. | Quercetin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
3 | Furthermore, quercetin induced activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) and subsequent mRNA and protein expression of the antioxidant enzymes, heme oxygenase-1 (HO-1), NAD(P)H dehydrogenase, quinone 1, and glutamate-cysteine ligase. | Quercetin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
4 | Our results suggest that quercetin suppresses LPS-induced oxidant production and adhesion molecule expression by inducing Nrf2 activation and antioxidant enzyme expression, which is partially mediated by p38; and the inhibitory effect of quercetin on adhesion molecule expression is not due to inhibition of NF-kappaB activation, but instead due to antioxidant-independent effects of HO-1. | Quercetin | NFE2 like bZIP transcription factor 2 | Homo sapiens |