Pub. Date : 2016 Aug
PMID : 27452633
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pharmacokinetic effects of curcumin on docetaxel mediated by OATP1B1, OATP1B3 and CYP450s. | Docetaxel | solute carrier organic anion transporter family member 1B3 | Homo sapiens |
| 2 | Curcumin exhibited potent inhibition on OATP1B1 and OATP1B3-mediated docetaxel uptake with IC50 values of 3.81 +- 1.19 muM and 33.70 +- 1.22 muM, respectively. | Docetaxel | solute carrier organic anion transporter family member 1B3 | Homo sapiens |
| 3 | The preclinical and clinical improved docetaxel"s therapeutic efficacy when co-administrated with curcumin may be due to the inhibition of curcumin on OATP1B1, OATP1B3 and HLMs activities. | Docetaxel | solute carrier organic anion transporter family member 1B3 | Homo sapiens |