Title : SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate.

Pub. Date : 2016 Nov

PMID : 27451147






1 Functional Relationships(s)
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1 Incubation of KRAS mutant CRC cells with knockdown of SLC25A22 with aspartate increased proliferation and reduced apoptosis, which required GOT1, indicating that oxaloacetate is required for cell survival. Aspartic Acid KRAS proto-oncogene, GTPase Homo sapiens