Title : Duloxetine Reduces Oxidative Stress, Apoptosis, and Ca2+ Entry Through Modulation of TRPM2 and TRPV1 Channels in the Hippocampus and Dorsal Root Ganglion of Rats.

Pub. Date : 2017 Aug

PMID : 27443158






4 Functional Relationships(s)
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1 Duloxetine Reduces Oxidative Stress, Apoptosis, and Ca2+ Entry Through Modulation of TRPM2 and TRPV1 Channels in the Hippocampus and Dorsal Root Ganglion of Rats. Duloxetine Hydrochloride transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus
2 Duloxetine (DULOX) in neurons reduced the effects of Ca2+ entry and reactive oxygen species (ROS) through glutamate receptors, and this reduction of effects may also occur through TRPM2 and TRPV1 channels. Duloxetine Hydrochloride transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus
3 TRPM2 and TRPV1 channel current densities, [Ca2+] concentration, apoptosis, caspase 3, caspase 9, mitochondrial depolarization, and intracellular ROS production values in the neurons were lower in the DULOX group than in controls. Duloxetine Hydrochloride transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus
4 In conclusion, TRPM2 and TRPV1 channels are involved in Ca2+ entry-induced neuronal death and modulation of the activity of these channels by DULOX treatment may account for their neuroprotective activity against apoptosis, excessive ROS production, and Ca2+ entry. Duloxetine Hydrochloride transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus