Title : Hyperpolarized (13)C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring.

Pub. Date : 2016

PMID : 27437179






2 Functional Relationships(s)
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Protein Name
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1 In particular, mutant IDH1 gliomas are associated with low levels of lactate dehydrogenase A (LDHA) and monocarboxylate transporters 1 and 4 (MCT1, MCT4), three proteins involved in pyruvate metabolism to lactate. Lactic Acid isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
2 Mutant IDH1 cells and tumors produced significantly less hyperpolarized [1-(13)C] lactate compared to GBM, consistent with their metabolic reprogramming. Lactic Acid isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens