Pub. Date : 2017 Mar
PMID : 27435108
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In bleomycin-induced fibrosis, periostin deficiency in structural or hematopoietic cells limits development of pulmonary fibrosis. | Bleomycin | periostin, osteoblast specific factor | Mus musculus |
| 2 | Additionally, connective tissue growth factor (CTGF) mRNA expression was increased in fibrocytes treated with periostin whereas CTGF and lysl oxidase (LOX) mRNA expression was low in bleomycin-treated periostin-/- fibrocytes. | Bleomycin | periostin, osteoblast specific factor | Mus musculus |
| 3 | These data suggest fibrocytes may augment bleomycin-induced fibrosis via secretion of periostin and other soluble factors that promote myofibroblast differentiation. | Bleomycin | periostin, osteoblast specific factor | Mus musculus |