Title : Role of vitamin D3 in regulation of interleukin-6 and osteopontin expression in liver of diabetic mice.

Pub. Date : 2016 Jul

PMID : 27424994






5 Functional Relationships(s)
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1 Role of vitamin D3 in regulation of interleukin-6 and osteopontin expression in liver of diabetic mice. Cholecalciferol interleukin 6 Mus musculus
2 OBJECTIVE: To study the link between hepatic interleukin-6 (IL-6) and osteopontin (OPN) gene expression and vitamin D3 status associated with type 1 diabetes in mice; and to evaluate the effects of vitamin D3 treatment (800 IU/kg of body weight for 6 weeks) on diabetes-induced impairments. Cholecalciferol interleukin 6 Mus musculus
3 OBJECTIVE: To study the link between hepatic interleukin-6 (IL-6) and osteopontin (OPN) gene expression and vitamin D3 status associated with type 1 diabetes in mice; and to evaluate the effects of vitamin D3 treatment (800 IU/kg of body weight for 6 weeks) on diabetes-induced impairments. Cholecalciferol interleukin 6 Mus musculus
4 Vitamin D3 treatment restored 25OHD3 that led to a substantial reduction of OPN and IL-6 mRNA levels. Cholecalciferol interleukin 6 Mus musculus
5 CONCLUSIONS: Diabetes-induced vitamin D3 deficiency was associated with increased hepatic levels of IL-6 and OPN mRNA and these changes were countered by vitamin D3 administration. Cholecalciferol interleukin 6 Mus musculus