Pub. Date : 2016 Jul
PMID : 27424994
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of vitamin D3 in regulation of interleukin-6 and osteopontin expression in liver of diabetic mice. | Cholecalciferol | interleukin 6 | Mus musculus |
| 2 | OBJECTIVE: To study the link between hepatic interleukin-6 (IL-6) and osteopontin (OPN) gene expression and vitamin D3 status associated with type 1 diabetes in mice; and to evaluate the effects of vitamin D3 treatment (800 IU/kg of body weight for 6 weeks) on diabetes-induced impairments. | Cholecalciferol | interleukin 6 | Mus musculus |
| 3 | OBJECTIVE: To study the link between hepatic interleukin-6 (IL-6) and osteopontin (OPN) gene expression and vitamin D3 status associated with type 1 diabetes in mice; and to evaluate the effects of vitamin D3 treatment (800 IU/kg of body weight for 6 weeks) on diabetes-induced impairments. | Cholecalciferol | interleukin 6 | Mus musculus |
| 4 | Vitamin D3 treatment restored 25OHD3 that led to a substantial reduction of OPN and IL-6 mRNA levels. | Cholecalciferol | interleukin 6 | Mus musculus |
| 5 | CONCLUSIONS: Diabetes-induced vitamin D3 deficiency was associated with increased hepatic levels of IL-6 and OPN mRNA and these changes were countered by vitamin D3 administration. | Cholecalciferol | interleukin 6 | Mus musculus |