Pub. Date : 2017 May
PMID : 27412761
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3beta and the ERK Pathway. | indirubin-3'-monoxime | glycogen synthase kinase 3 beta | Homo sapiens |
| 2 | Indirubin-3-oxime treatment significantly reversed the altered activity of both the PI3-K/Akt/GSK3beta cascade and the ERK pathway induced by H2O2. | indirubin-3'-monoxime | glycogen synthase kinase 3 beta | Homo sapiens |
| 3 | These results strongly suggest that indirubin-3-oxime prevents H2O2-induced apoptosis via concurrent inhibiting GSK3beta and the ERK pathway in SH-SY5Y cells, providing support for the use of indirubin-3-oxime to treat neurodegenerative disorders caused or exacerbated by oxidative stress. | indirubin-3'-monoxime | glycogen synthase kinase 3 beta | Homo sapiens |